The Rotary Club of Chicago is an organization with the stated purpose of bringing together business and professional leaders to provide humanitarian service, encourage high ethical standards in all vocations, and help build goodwill and peace in the world. It is a secular organization open to all persons regardless of race, color, creed, gender, or political preference.

The Rotary Club of Chicago is the first Rotary Club in the world founded in 1905.

The most notable current global project of Rotary International, the umbrella organization of all Rotary Clubs, PolioPlus, is contributing to the global eradication of polio. Since beginning the project in 1985, Rotarians have contributed over US$850 million and tens of thousands of volunteer-hours, leading to the inoculation of more than two billion of the world's children. Inspired by Rotary's commitment, the World Health Organization (WHO) passed a resolution in 1988 to eradicate polio by 2000. Now a partner in the Global Polio Eradication Initiative (GPEI) with WHO, UNICEF and the U.S. Centers for Disease Control and Prevention, Rotary is recognized by the United Nations as the key private partner in the eradication effort.

In 2008, Rotary received a $100 million challenge grant from the Bill and Melinda Gates Foundation. Rotary committed to raising $100 million. In January 2009, Bill Gates announced a second challenge grant of $255 million. Rotary again committed to raising another $100 million. In total, Rotary will raise $200 million by June 30, 2012. Together, the Gates Foundation and Rotary have committed $555 million toward the eradication of polio. At the time of the second challenge grant, Bill Gates said:

"We know that it’s a formidable challenge to eradicate a disease that has killed and crippled children since at least the time of the ancient Egyptians. We don’t know exactly when the last child will be affected. But we do have the vaccines to wipe it out. Countries do have the will to deploy all the tools at their disposal. If we all have the fortitude to see this effort through to the end, then we will eradicate polio."